Five weeks into the season, we're doing well: against the spread, to be exact. But nothing is guaranteed this week, which offers a. NFL odds and spreads for the latest NFL games. NFL Odds: Week 1 .. Betting on the favorite means the team must win by at least fourteen points to cover the. Rejoice, NFL bettors— Week 6 is almost here. Normally, bettors probably shouldn 't throw much of a party for another line of tough games.